ResourcesAs your subject matter expert, TGCA shares our knowledge of the intricacies of molecular therapies, facilitating the identification of clinical characteristics associated with optimal outcomes.
TGCA: Defining, Navigating, Advancing Genetic Medicine
The need for new and innovative approaches to treat disease has never been more critical. The development and utilization of molecular therapies is revolutionizing healthcare. Cell therapy, gene...
The Random Genetic Event that Changed the World
Where did COVID-19 come from? Viruses infect every species on Earth: animals, plants and even bacteria. A virus can only infect a limited range of species. Typically these are related species, which...
SSRI Use is Associated with Reduced Opioid Use 30 Days After Total Knee Arthroplasty
There is a complicated two-way biological and psychological relationship between pain and depression. A poster from the University of Washington Medical Center presented at the 2019 American Pain...
Bigler RL., “CAR T-Cell Therapy: Genetically Programming the Immune System to Attack Malignant Cells.” Pharmacy Times. February 2020. Click to View.
Bigler RL., “Pharmacogenomics for Precision Specialty Pharmacy Care.” Specialty Pharmacy Times. October 2019. Volume 10, Number 6. Click to View.
Bigler RL. The Axonal Transcriptome of Human Embryonic Stem Cell Derived Neurons and The Cell Autonomous Transcriptional Response to Axon Injury. Dissertation, The University of North Carolina at Chapel Hill. Chapel Hill: Carolina Digital Repository, 2017. Click to View.
Bigler RL, Kamande JW, Dumitru R, Niedringhaus M, Taylor AM., “Messenger RNAs localized to distal projections of human stem cell derived neurons.” Scientific Reports. 2017 Apr 4;7(1):611. Click to View
Nagendran T, Bigler RL, Larsen R, Philpot BD, Taylor AM., “Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.” Nature Communications. 2017 Sep 20;8(1):625. Click to View.
Slevin MK, Meaux S, Welch JD, Bigler R, Miliani de Marval PL, Su W, Rhoads RE, Prins JF, Marzluff WF., “Deep sequencing shows multiple oligouridylations are required for 3′ to 5′ degradation of histone mRNAs on polyribosomes.” Molecular Cell. 2014 Mar 20;53(6):1020-30. Click to View.
Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ., “The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation.” Molecular Cell. 2012 Nov 30;48(4):612-26. Click to View.
Dong S, Wang Y, Cassidy-Amstutz C, Lu G, Bigler R, Jezyk MR, Li C, Hall TM, Wang Z., “Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains.” Journal of Biological Chemistry. 2011 Jul 29;286(30):26732-42. Click to View.